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KMID : 0624620080410070523
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BMB Reports
2008 Volume.41 No. 7 p.523 ~ p.528
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BMI-1026 treatment can induce SAHF formation by activation of Erk1/2
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Seo Hyun-Joo
Park Hye-Jeong
Choi Hyung-Su
Hwang So-Yoon
Park Jeong-Soo
Seong Yeon-Sun
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Abstract
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BMI-1026 is a synthetic aminopyrimidine compound that targets cyclin dependent kinases (cdks) and was initially designed as a potential anticancer drug. Even though it has been well documented that BMI-1026 is a potent cdk inhibitor, little is known about the cellular effects of this compound. In this study, we examined the effects of BMI-1026 treatment on inducing premature senescence and then evaluated the biochemical features of BMI-1026-induced premature senescence. From these experiments we determined that BMI-1026 treatment produced several biochemical features of premature senescence and also stimulated expression of mitogen activated protein kinase (MAPK) family proteins. BMI-1026 treatment caused nuclear translocation of activated Erk1/2 and the formation of senescence associated heterochromatin foci in 5 days. The heterochromatin foci formation was perturbed by inhibition of Erk1/2 activation. [BMB reports 2008; 41(7): 523-528]
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KEYWORD
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BMI-1026, cdk, Erk1/2, Senescence associated heterochromatin foci (SAHF)
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